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Sunday, March 31, 2013
Saturday, March 30, 2013
Top 10 Internet Marketing Forums | Top 10 Lists | TopTenPlus ...
Internet has a lot more to offer apart from the endless and wonderful communication ways of people from all over the world. The world wide web has now emerged and become one of the most top thing for internet marketers. People are now selling and promoting their products with the help of internet and thus they need and acquire the help of the top communities which can help them in promotion of their stuff to their targeted audience. The forums are a great way to get the attention of people across the globe so the best thing about it is that you can get the attention of the people and can communicate with the users properly in forums. Apart from other forums there are many popular internet marketing forums too which have gained a lot of popularity in the last 2-3 years. Hundreds and thousands of active users of these online internet marketing forums helps business grow easily. Lets have a talk about these 10 Best Forums which we can use for online marketing purposes.
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Click Bank Success Forum
Click Bank Success Forum is actually designed for the online marketers who want to do their affiliate marketing business in the forum. This is a good and active community forum where you can share your affiliate links with the people to promote any product and get your commission based on your sales. This is more of a kind of online business sales you can choose from.
This New Bloggers forum started by Garry Con is a wonderful creation and is for the sole purpose of the enthusiast bloggers and webmasters to help them earn money online. This forum is good for newbie bloggers watching out for the new and working ways to successful earning for them. This is a good forum to make yourself noticed and thus to share some useful thing with people.
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High Rankings SEO Forum
This name suggests the most important and ruling authority of the today?s world ? SEO ? . We must keep in mind that SEO is not the soul of internet marketing these days but still it holds a lot better position to impact your sales and getting product exposure. This high ranking SEO forum can help you all things regarding SEO and other useful stuff to rank higher in search to make more sales.
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Net Business Talk Forum
The Net business Talk forum is a good platform for webmasters and internet marketers to share their thoughts and also share some cool tips on how to start and build successful online business. You can join this forum if you want to discuss or debate any kind of talk about which business is best and how to get to top on that to boost sales and all other things.
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IM4Newbies
IM4Newbies helps new entrepreneurs and webmasters to start an online business and how to promote them to people visiting these forums. They also offer huge options for companies and individuals and help them do a great marketing service in order to survive in the online business. Help is provided with help of videos and trainings which is the best part of this forum.
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30 Days Challenge Forum
The 30 Day challenge forum is a new online marketing forum which has few members yet but you can still get a lot from this newly born forum and soon get a premium membership if you keep on getting and giving useful information to the people coming there. The guys of the forum have named it 30 day challenge of making a business successful with this 30 day course.
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Wicked Fire
Wicked fire is another wonderful SEO marketing forum which also includes internet marketing business strategies and a lot more. The Wicked fire is similar to digital point forums and you can sell, buy or trade anything related to blogging, internet marketing and promote your business easily with people and webmaster coming up there in the community.
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V7 Community
The V7 Community focuses more on the the web development and issues related with web development process. Need any help regarding the look and problem of your website you can ask for help from the loyal members of the v7? community and they will be ready to help you get what you want.
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Digital Point Forums
Digital Forums is another good place for people to search out for good content and some good ideas to earn money and a passive income from their business. It is a great forum and with the new and fresh look of digital point forums you can get each and everything you need. You can browse through hundreds of threads and posts and learn some good ways to master in online business.
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Warrior Forums
The Warrior Forums is the Number 1 best online internet marketing forum which is the best solution for newbies and also for skilled and professionals. It is the most simplest of all the online forums and you can learn a good deal and get an idea of how online internet marketing works. The warriors are great at giving help especially to the newbies and help them as much as possible. This is the reason that warriors have won the hearts of millions of people worldwide and have made this forum the Best Forum for Internet Marketing and Business.
Source: http://toptenplus.com/top-10-online-internet-marketing-forums-for-link-building/
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With Alternative Offers From Blackstone & Icahn On The Table, Dell Filing Shows It Will Push Ahead With $24.4B Silver Lake Merger
Dell announced today that it has filed its initial proxy materials with the SEC in connection with a merger agreement between Dell, its Chairman and CEO Michael Dell and Silver Lake Partners. Under the terms of the deal, shareholders would received $13.65 in cash for each share of stock, which would be valued at about $24.4 billion.Source: http://feedproxy.google.com/~r/Techcrunch/~3/vGDXIV-NoCY/
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Facebook data shows picture of same-sex marriage support
Noticed a lot of profile pictures changing this week on Facebook? It was a nationwide trend, as users on the social network responded to the Human Rights Campaign's request for them to substitute a red-and-pink equal sign for their profile photos in support of same-sex marriage, with the nation's highest court hearing two cases on the issue.
Facebook knows, of course, whenever someone changes their profile picture, and there's a normal daily rhythm for American users. But Facebook's investigation showed a huge bump in picture changes just after the Human Rights Campaign began its effort.
"While millions of U.S. Facebook users update their profile photos on a given day, we found that significantly more users ? roughly 2.7 million (120 percent) more, updated their profile photo on Tuesday, March 26 compared to the previous Tuesday," notes Eytan Bakshy, a researcher on the Facebook Data Science Team, in the post.
Profile pic changes skyrocketed among younger users, especially those around the age of 30; teenagers and seniors didn't get quite as much into the spirit.
There were also some highly significant geographical trends, as illustrated by the map above. The darker the color of the country, the more people changed their profile picture. The most active county in the country was Washtenaw, in Michigan, home to Ann Arbor and the University of Michigan ? and the other most active counties also contained major colleges and universities.
As some commenting on the Facebook blog post have pointed out, there's no way to know whether all these profile picture updates were in support of gay marriage, since users could just as easily be changing their picture to indicate opposition to gay marriage (or just a new look). But the correlation with college towns and the deliberate and visible campaign by the Human Rights Campaign suggest that it was mostly supportive.
The rest of the data and a few more observations by the Facebook Data Science Team can be found at the blog post itself.
Devin Coldewey is a contributing writer for NBC News Digital. His personal website is coldewey.cc.
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iFixit breaks open an HTC One, literally
Considering its sleek, primarily aluminum construction we never thought the HTC One was going be easy to crack open. But, it seems not even iFixit was completely prepared for the challenge of picking one apart. Since there are no screws used in the construction of the body, the fearless hackers needed to turn to a heat gun, a suction cup and a metal spudger to gain access to the internals. Underneath the swaths of aluminum and glass it turns out most of the components are covered in foil-like copper shielding that is quite difficult to deal with. There are a few screws inside, however, like the pair of fasteners that connect the 2,300mAh battery's cable to the motherboard. In the end, iFixit handed the One its namesake on the repairability scale -- meaning this sucker is practically impossible to pull apart and reassemble. To see the complete and careful destruction of HTC's latest flagship hit up the source.
Filed under: Cellphones, Mobile, HTC
Source: iFixit
Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/G6HMIRLVyy0/
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Friday, March 29, 2013
Doug Ross @ Journal: Our Society's New Official Religion
Courtesy of Tyler Durden, Charles Gave describes the parameters of his new belief system.
Pity there's no separation of this church and state.
...my new faith can be understood as follows:1. Government allocates capital better than the private sector, and should use interest rates, exchange rates, price fixing, price controls or whatever artifice it deems fit to ensure that capital goes to where it is properly directed.
2.. The alpha and omega of the central bank?s proper role is to finance government spending.
3.. Money belongs to the government, as we have seen properly demonstrated this week in Cyprus.
4.. Property rights, the antediluvian obsession of the market fundamentalists, have been subject to a doctrinal revision ?the template? as also shown this week in the eastern Mediterranean.
5.. As a result of this new paradigm, asset prices must rise for the foreseeable future so long as Heli I decrees that the money printers keep printing. How can asset prices fall while the US central bank is printing more than $80bn a month? Even the unreformed Bundesbankers will surely grasp that if the European Central Bank did the same thing, the euro's problems would disappear overnight and prosperity would swiftly return to southern Europe, (Really, Germans should not be allowed into politics until they have had a primer indoctrination at either Cambridge or Princeton.)
6.. More money creates more wealth, and more wealth, especially in real estate, creates more jobs?evidence to the contrary in Spain only represents a small setback on this road to happiness. As we all know, a rise in real estate prices leads to a massive increase in productivity, a prerequisite for an increase in the standard of living.
7.. Services or goods provided to the population by the government, borrowing money from the central bank to pay the fellows who produce the goods that nobody needs with money that does not exist, will add tremendously to the GDP. This is a sure sign that the right policy is being pursued.
8.. These goods and services anyway have a higher moral value than the ones produced in the private sector. One should simply compare the "social usefulness" (a favorite notion of Lenin and Stalin) of a nurse versus a hedge fund manager to be convinced. I rest my case.
So from now on, I will buy what the US, UK, French, Spanish, or for that matter Greek governments and central banks tell me to buy. I cannot afford to offend the new clergy. As a market ?intellectual? the risks to my social standing, not to mention career prospects, are too high. One day if I keep my nose clean and my thoughts pure, I may just be admitted to the College of Cardinals.
Pity there's no separation of this church and state.
Image: William Banzai.
Source: http://directorblue.blogspot.com/2013/03/our-societys-new-and-official-religion.html
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The final OUYA retail console is ready, we go hands-on
It's been a long time coming, and now the Android-powered, Kickstarter-funded OUYA video game console is finally heading to backers. Sure, the final retail units for non-backers won't be available until June, but around 50,000 lucky folks who pledged over $99 to OUYA's massively successful campaign will be receiving their units in the coming days. We've already heard what developers have to say about it, but this week we got our first hands-on with the miniature, Tegra 3-powered game console we've been hearing so much about since last summer.
Is it the "best Tegra 3 device on the market," as OUYA's claimed? Let's find out!
Filed under: Gaming, Software, HD
Source: http://www.engadget.com/2013/03/28/ouya-hands-on/
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Rare View Reveals How Earth's Crust Forms
One of the Earth's best-ever baby pictures reveals how crust forms at the biggest volcanic feature on the planet.
The detailed look at molten magma beneath a mid-ocean ridge, one of the giant undersea cracks that ring the globe like seams on a baseball, sheds light on the driving forces behind plate tectonics. The results of the study are published today (March 27) in the journal Nature.
Most of the Earth (70 percent) is covered by oceanic crust, mainly basalt, formed from lava that burbles out ofmid-ocean ridges. The ridges run across some 40,000 miles (65,000 kilometers) of the seafloor. They mark where crust pulls apart, leaving space for hotter mantle rock underneath to rise up and melt.
But the particulars of this process have been fuzzy. Geoscientists lacked clear images of structures beneath the mid-ocean ridges, which would reveal how magma moves to the surface.
"The upper mantle melting region is a deep and difficult target," said Kerry Key, lead study author and a seismologist at the Scripps Institution of Oceanography in San Diego.
Key and his co-authors peered into this mysterious zone beneath the northern East Pacific Rise, a fast-spreading mid-ocean ridge near Costa Rica.
Plates pull apart, make new crust
Their new image is akin to a sonogram of the Earth, but instead of sound waves, the researchers used a technique called electromagnetic imaging, which looks for subtle variations in Earth's naturally occurring electric and magnetic fields. The variations reveal different layers and liquid beneath the surface.
Key discovered a symmetrical, narrow melt zone beneath the East Pacific Rise. This implies the mantle is simply filling space created by spreading plates, he said. If the rising mantle were pushing the plates apart, there would likely be evidence of localized convection, such as broader, asymmetrical melting.
The study supports one of the dominant theories (the passive flow model) of how mid-ocean ridges work, the researchers said. Earth's crust is like a giant conveyor belt, with plates spreading apart at mid-ocean ridges and diving into the mantle for recycling at subduction zones, Key explained. The plates ride on giant convection cells in the mantle, but mid-ocean ridges aren't linked to these massive swirls. Instead, the ridges' localized melting comes from the space created by slip-sliding tectonic plates, geologists think. However, there's ongoing debate as to whether the driving force is pull at subduction zones ? the passive flow model ? or push from magma coming up at ridges. [Infographic: Tallest Mountain to Deepest Ocean Trench]
"Our data looks just like the passive flow model," Key told OurAmazingPlanet. "It agrees with what everybody thinks should be going on, but we haven't had a good image before. It looks like something somebody would have drawn in a textbook based on what we thought was going on."
How the mantle melts
The results also confirm models of mantle melting based on rocks scraped off the seafloor at mid-ocean ridges. Sometimes, pieces of the mantle are carried up to the surface with erupting lava, giving geologists a glimpse into this inaccessible part of the Earth.
The first gooey mantle rocks to melt have a high concentration of impurities, such as carbon dioxide and then water, Key said. Finally, between a depth of 37 miles (60 km) and the surface, the melt really gets going, with about 10 percent of the mantle transformed to liquid rock. Just below the surface, a vertical channel to the east of the ridge connects the magma reservoir to the fissures and volcanoes at the surface.
"This really helps to fill out the picture of how ridges work and how the melt gets from where it's formed to the surface," said Don Forsyth, a marine geophysicist at Brown University, who was not involved in the study.
However, Forsyth would like to see additional surveys along the north-south ridge axis to confirm there's no mantle convection. "I think they have strong supporting evidence for passive upwelling, but the symmetry by itself doesn't necessarily prove that it's passive," he told OurAmazingPlanet.
Email Becky Oskin or follow her @beckyoskin. Follow us?@OAPlanet, Facebook?or Google +. Original article on LiveScience's OurAmazingPlanet.
Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.Source: http://news.yahoo.com/rare-view-reveals-earths-crust-forms-180256765.html
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UN envoy condemns 'Malala-style' attack on Pakistani teacher
By Becky Bratu, Staff Writer, NBC News
A female Pakistani teacher and mother of three was shot dead by two motorcyclists near the school where she taught in Peshawar, Pakistan.
UN Special Envoy for Global Education Gordon Brown has condemned the shooting as a "Malala-style" incident. Malala Yousafzai, 15, is a young advocate for women's education who was shot in the face at point-blank range by Taliban gunmen on Oct. 9 in Pakistan?s Swat Valley.
Shahnaz Bibi was a headmistress and a teacher at a primary school. She was on her way to work, traveling with her young son, when the attack took place. Her son, Daniel, 12, was unhurt.
"I want justice," he told ITV?s Penny Marshall. "My mother suffered an injustice, and I want the world to know that."
His father must now care for Daniel and his two sisters alone.
Yousafzai was one of the first to sign a petition asking the Pakistani government to protect women and girls pursuing an education.
"I think the petition that?s now being started and led by Malala herself is demanding that the Pakistani government not only get girls to school but protect teachers and girls when they go to school from extremist sects that are trying to deny girls in the 21st century the right to education," Brown, the former British prime minister, said.
Several female aid workers and teachers have died in similar attacks in Pakistan.
Thursday, March 28, 2013
Computer chips: Building upward safely
Mar. 27, 2013 ? A computer model provides important clues for the production of tightly packed electronic components.
Greater numbers of ever-smaller components are required to fit on computer chips to meet the ongoing demands of miniaturizing electronic devices. Consequently, computer chips are becoming increasingly crowded. Designers of electronic architectures have therefore followed the lead of urban planners and started to build upward. In so-called 'three-dimensional (3D) packages', for example, several flat, two-dimensional chips can be stacked on top of each other using vertical joints.
Controlling the properties of these complex structures is no easy task, as many factors come into play during production. Faxing Che and Hongyu Li and co-workers from the A*STAR Institute of Microelectronics, Singapore, have now developed a powerful modeling method that allows large-scale simulations -- and optimization -- of the fabrication process, which provides welcome assistance to designers.
Among the challenges of producing tightly packed computer chips is the need to prevent warpage of the underlying silicon wafer as electronics components are stacked on it. Warpage leads to a number of unwanted effects. "Strong warpage can cause wafer breakage, it makes tight packing more difficult and some processing machines cannot handle high-warpage wafers," explains Li. The degree of warpage depends on many design and process parameters, and optimizing the procedure experimentally is time-consuming and costly.
Using their computer model, Che and Li studied a wide range of parameters that influence the warpage of an 8-inch diameter silicon wafer. They focused, in particular, on how a silicon substrate responds to the deposition of layers of copper -- through which electrical currents eventually flow. "This is the first time that a model has been able to predict warpage [at] the level of the entire wafer," says Li. Moreover, the stress on the wafer can be determined accurately. The calculated values agreed well with experimental data. Importantly, with the computer simulations, the researchers could explore regimes that cannot be easily studied experimentally, such as how the depth of the connections between layers influences wafer warpage.
The next goal is to simulate even larger wafers with variable connection sizes, explains Li. "Today, there are two industry standards for 3D packaging applications, 8-inch and 12-inch wafers, but the latter are becoming increasingly important," she says. The team's model is applicable to these larger wafers, too, but it requires optimization. Currently, Che, Li and their co-workers are collecting warpage and stress data for 12-inch wafers. They will use these data for developing their model further, according to Li.
The A*STAR-affiliated researchers contributing to this research are from the Institute of Microelectronics
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The above story is reprinted from materials provided by The Agency for Science, Technology and Research (A*STAR).
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Faxing Che, Hongyu Y. Li, Xiaowu Zhang, Shan Gao, Kenghwa H. Teo. Development of Wafer-Level Warpage and Stress Modeling Methodology and Its Application in Process Optimization for TSV Wafers. IEEE Transactions on Components, Packaging and Manufacturing Technology, 2012; 2 (6): 944 DOI: 10.1109/TCPMT.2012.2192732
Note: If no author is given, the source is cited instead.
Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.
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Dana White?s latest video blog shows he is a fan of shooting guns, riding motorcycles and apple-picking
With no fight this week, UFC president Dana White released a video blog that shows what he and his "idiot friends" do when visiting his place in Maine. Yes, there's plenty of NSFW language. Take a look and see what White and his friends are up to, including:
1. Talk one friend into trying the spiciest hot sauce ever.
2. Blow things up.
3. Shoot guns while calling each other a nickname for a cat.
4. Apple-picking, though it doesn't look like they're picking honeycrisp apples, the finest of all apple varieties.
5. Milk goats in a way that looks pretty uncomfortable for the goat.
6. Drive motorcycles.
[Also: Nick Diaz can cry foul all he wants, but he's not getting a rematch with GSP]
And a little advice for Nick the Tooth. I was once told at an Indian restaurant, after eating very spicy food, that beer or soda pop are your best bets to cool a burning mouth.
Memorable Moments from Yahoo! Sports:
Other popular content on Yahoo! Sports:
? Top seeds L'ville, Kansas in the way of All-Big Ten Final Four
? Watch: Who could crash the Final Four?
? Report: Seahawks may have multiple trade partners for Matt Flynn
? NASCAR Power Rankings: A (Junior) Nation rises
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AMD unveils game streaming platform with Radeon Sky Graphics
AMD Delivers Unified Gaming Strategy at GDC 2013
- AMD launches powerful cloud gaming platform AMD Radeon Sky Series graphics, extends "Never Settle: Reloaded" program with "BioShock Infinite" and showcases sneak peek
of new "Ruby" demo -
SAN FRANCISCO - Mar. 26, 2013 - Today at the Game Developers Conference (GDC) AMD (NYSE: AMD) unveiled its leadership strategy for the worldwide gaming market. AMD's Unified Gaming Strategy comprehensively addresses how AMD will drive the gaming market across consoles, cloud platforms, tablets and PCs. By working with the world's leading hardware and game developers, and by continuing to be a leader in the market by providing the most innovative graphics technologies, AMD is effectively positioned to drive the next revolution in gaming.
Gaming Evolved, launched three years ago at GDC, is at the core of the AMD Unified Gaming Strategy, and has been the driving force behind the revolutionary "Never Settle" gaming bundles and a major factor behind the adoption of powerful AMD engines in the latest next- generation gaming consoles. Building on this momentum, AMD today introduced AMD RadeonTM Sky Graphics, the cornerstone of AMD's industry-leading cloud gaming platform.
"Real-time gaming through the cloud represents a significant opportunity and AMD is poised to lead in this vertical thanks to our extensive graphics hardware and software capabilities," said David Cummings, senior director, AMD Professional Graphics. "AMD is working closely with CiiNow,G-Cluster, Otoy and Ubitus to deliver exceptional AMD RadeonTM gaming experiences to the cloud."
Built from the ground up on the AMD Graphics Core Next architecture, this best-in-class graphics technology will lead the way in performance and define cloud gaming experiences for gamers. By working with industry-leaders like CiiNow, G-Cluster, Otoy and Ubitus, AMD has developed flexible cloud gaming technology and designed a solution that enables game developers and service providers to deliver a world-class content experience to millions of gamers whether it's through PCs, tablets, Smart TVs or mobile devices. Powering this seamless experience is AMD RapidFire technology, enabling highly efficient and responsive game streaming.
Continued Momentum in Discrete Graphics Lineup
With the arrival of the AMD RadeonTM HD 7790 graphics card last week, AMD continues to deliver outstanding graphics products. Based on the award-winning Graphics Core Next architecture, the AMD Radeon HD 7790 GPU was made for gamers looking to play the latest games, including Gaming Evolved titles such as Crysis 3 and Tomb Raider, at the right price point.
"We continue to innovate and push the boundaries of our discrete graphics products," said Matt Skynner, corporate vice president and general manager, AMD Graphics. "Gamers demand the best experience across all of our products and with the AMD Radeon HD 7790 GPU, they receive the latest AMD Radeon technology at a competitive price point."
Packing in AMD Eyefinity technology and the award-winning Graphics Core Next architecture, the AMD Radeon HD 7790 GPU also features an enhanced version of AMD PowerTune technology, which enables higher performance and immersive gameplay to gaming rigs. This latest addition to the AMD RadeonTM HD 7000 series of graphics products is the ultimate choice for gamers looking to maximize their gaming experience in the USD$150 MSRP range. The AMD Radeon HD 7790 GPU is expected to be available from all AMD add-in-board partners during the first week of April.
Ruby: Rebooted, Reborn, Reloaded
GDC also marked the 10th anniversary of the launch of the original iconic AMD "Ruby" demo. To celebrate this milestone, AMD unveiled a sneak peek of its remodeled and reinvented Ruby, which was designed and developed by IllFonic, and harnesses the power of Crytek's CryEngine? 3 development engine. The latest AMD "Ruby" demo is still under production and is designed to highlight real-world gaming possibilities of AMD Radeon graphics technology. It will be unveiled to the world in the coming weeks.
BioShock Infinite: The Best of DirectX? 11
As part of the "Never Settle: Reloaded" bundle, AMD is proud to announce the arrival of "BioShock: Infinite." With DirectX 11 PC-exclusive features such as anti-aliasing, texture detail, texture filtering, dynamic shadows and more, AMD is empowering gamers to unleash the most realistic gaming experience. Each of these features were developed in close collaboration with Irrational Games and the AMD Gaming Evolved team, ensuring the best experience for PC gamers choosing AMD Radeon graphics cards.
"Fifteen years ago, Irrational Games got its start making PC games, and the PC gaming experience has always been near and dear to our hearts. Working with AMD allowed us to make the most of the DirectX 11-powered graphics," said, Chris Kline, technical director, Irrational Games.
Source: http://www.engadget.com/2013/03/27/amd-cloud-game-streaming-radeon-sky-graphics/
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Wednesday, March 27, 2013
Cancer biologists find DNA-damaging toxins in common plant-based foods
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Public release date: 27-Mar-2013[ | E-mail |
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Johns Hopkins Medicine
Liquid smoke, black and green teas and coffee produced levels of cell DNA damage comparable to chemo drugs
In a laboratory study pairing food chemistry and cancer biology, scientists at the Johns Hopkins Kimmel Cancer Center tested the potentially harmful effect of foods and flavorings on the DNA of cells. They found that liquid smoke flavoring, black and green teas and coffee activated the highest levels of a well-known, cancer-linked gene called p53.
The p53 gene becomes activated when DNA is damaged. Its gene product makes repair proteins that mend DNA. The higher the level of DNA damage, the more p53 becomes activated.
"We don't know much about the foods we eat and how they affect cells in our bodies," says Scott Kern, M.D., the Kovler Professor of Oncology and Pathology at the Johns Hopkins University School of Medicine. "But it's clear that plants contain many compounds that are meant to deter humans and animals from eating them, like cellulose in stems and bitter-tasting tannins in leaves and beans we use to make teas and coffees, and their impact needs to be assessed."
Kern cautioned that his studies do not suggest people should stop using tea, coffee or flavorings, but do suggest the need for further research.
The Johns Hopkins study began a year ago when graduate student Samuel Gilbert, working in Kern's laboratory, noted that a test Kern had developed to detect p53 activity had never been used to identify DNA-damaging substances in food.
For the study, published online February 8 in Food and Chemical Toxicology, Kern and his team sought advice from scientists at the U.S. Department of Agriculture about food products and flavorings. "To do this study well, we had to think like food chemists to extract chemicals from food and dilute food products to levels that occur in a normal diet," he says.
Using Kern's test for p53 activity, which makes a fluorescent compound that "glows" when p53 is activated, the scientists mixed dilutions of the food products and flavorings with human cells and grew them in laboratory dishes for 18 hours.
Measuring and comparing p53 activity with baseline levels, the scientists found that liquid smoke flavoring, black and green teas and coffee showed up to nearly 30-fold increases in p53 activity, which was on par with their tests of p53 activity caused by a chemotherapy drug called etoposide.
Previous studies have shown that liquid smoke flavoring damages DNA in animal models, so Kern's team analyzed p53 activity triggered by the chemicals found in liquid smoke. Postdoctoral fellow Zulfiquer Hossain tracked down the chemicals responsible for the p53 activity. The strongest p53 activity was found in two chemicals: pyrogallol and gallic acid. Pyrogallol, commonly found in smoked foods, is also found in cigarette smoke, hair dye, tea, coffee, bread crust, roasted malt and cocoa powder, according to Kern. Gallic acid, a variant of pyrogallol, is found in teas and coffees.
Kern says that more studies are needed to examine the type of DNA damage caused by pyrogallol and gallic acid, but there could be ways to remove the two chemicals from foods and flavorings.
"We found that Scotch whiskey, which has a smoky flavor and could be a substitute for liquid smoke, had minimal effect on p53 activity in our tests," says Kern.
Liquid smoke, produced from the distilled condensation of natural smoke, is often used to add smoky flavor to sausages, other meats and vegan meat substitutes. It gained popularity when sausage manufacturers switched from natural casings to smoke-blocking artificial casings.
Other flavorings like fish and oyster sauces, tabasco and soy sauces, and black bean sauces showed minimal p53 effects in Kern's tests, as did soybean paste, kim chee, wasabi powder, hickory smoke powders and smoked paprika.
###
Funding for the study was provided by the National Institutes of Health's National Cancer Institute (CA62924) and the Everett and Marjorie Kovler Professorship in Pancreas Cancer Research.
In addition to Kern, Gilbert and Hossain, other scientists involved in the research include Kalpesh Patel, Soma Ghosh, and Anil Bhunia from Johns Hopkins.
On the Web: hopkinscancer.org
Media Contacts:
Vanessa Wasta, 410-614-2916
wasta@jhmi.edu
Amy Mone, 410-614-2915
amone@jhmi.edu
March 27, 2013
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Public release date: 27-Mar-2013[ | E-mail |
Share ] Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine
Liquid smoke, black and green teas and coffee produced levels of cell DNA damage comparable to chemo drugs
In a laboratory study pairing food chemistry and cancer biology, scientists at the Johns Hopkins Kimmel Cancer Center tested the potentially harmful effect of foods and flavorings on the DNA of cells. They found that liquid smoke flavoring, black and green teas and coffee activated the highest levels of a well-known, cancer-linked gene called p53.
The p53 gene becomes activated when DNA is damaged. Its gene product makes repair proteins that mend DNA. The higher the level of DNA damage, the more p53 becomes activated.
"We don't know much about the foods we eat and how they affect cells in our bodies," says Scott Kern, M.D., the Kovler Professor of Oncology and Pathology at the Johns Hopkins University School of Medicine. "But it's clear that plants contain many compounds that are meant to deter humans and animals from eating them, like cellulose in stems and bitter-tasting tannins in leaves and beans we use to make teas and coffees, and their impact needs to be assessed."
Kern cautioned that his studies do not suggest people should stop using tea, coffee or flavorings, but do suggest the need for further research.
The Johns Hopkins study began a year ago when graduate student Samuel Gilbert, working in Kern's laboratory, noted that a test Kern had developed to detect p53 activity had never been used to identify DNA-damaging substances in food.
For the study, published online February 8 in Food and Chemical Toxicology, Kern and his team sought advice from scientists at the U.S. Department of Agriculture about food products and flavorings. "To do this study well, we had to think like food chemists to extract chemicals from food and dilute food products to levels that occur in a normal diet," he says.
Using Kern's test for p53 activity, which makes a fluorescent compound that "glows" when p53 is activated, the scientists mixed dilutions of the food products and flavorings with human cells and grew them in laboratory dishes for 18 hours.
Measuring and comparing p53 activity with baseline levels, the scientists found that liquid smoke flavoring, black and green teas and coffee showed up to nearly 30-fold increases in p53 activity, which was on par with their tests of p53 activity caused by a chemotherapy drug called etoposide.
Previous studies have shown that liquid smoke flavoring damages DNA in animal models, so Kern's team analyzed p53 activity triggered by the chemicals found in liquid smoke. Postdoctoral fellow Zulfiquer Hossain tracked down the chemicals responsible for the p53 activity. The strongest p53 activity was found in two chemicals: pyrogallol and gallic acid. Pyrogallol, commonly found in smoked foods, is also found in cigarette smoke, hair dye, tea, coffee, bread crust, roasted malt and cocoa powder, according to Kern. Gallic acid, a variant of pyrogallol, is found in teas and coffees.
Kern says that more studies are needed to examine the type of DNA damage caused by pyrogallol and gallic acid, but there could be ways to remove the two chemicals from foods and flavorings.
"We found that Scotch whiskey, which has a smoky flavor and could be a substitute for liquid smoke, had minimal effect on p53 activity in our tests," says Kern.
Liquid smoke, produced from the distilled condensation of natural smoke, is often used to add smoky flavor to sausages, other meats and vegan meat substitutes. It gained popularity when sausage manufacturers switched from natural casings to smoke-blocking artificial casings.
Other flavorings like fish and oyster sauces, tabasco and soy sauces, and black bean sauces showed minimal p53 effects in Kern's tests, as did soybean paste, kim chee, wasabi powder, hickory smoke powders and smoked paprika.
###
Funding for the study was provided by the National Institutes of Health's National Cancer Institute (CA62924) and the Everett and Marjorie Kovler Professorship in Pancreas Cancer Research.
In addition to Kern, Gilbert and Hossain, other scientists involved in the research include Kalpesh Patel, Soma Ghosh, and Anil Bhunia from Johns Hopkins.
On the Web: hopkinscancer.org
Media Contacts:
Vanessa Wasta, 410-614-2916
wasta@jhmi.edu
Amy Mone, 410-614-2915
amone@jhmi.edu
March 27, 2013
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Source: http://www.eurekalert.org/pub_releases/2013-03/jhm-cbf032713.php
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Brent steady near $108 on worries over Cyprus, euro zone oil demand
By Jessica Jaganathan
SINGAPORE (Reuters) - Brent crude remained steady above $108 a barrel on Tuesday on concerns the Cyprus bailout could set a new precedent in restructuring the euro zone banking sector, again feeding worries about the European economy and its demand for oil.
Jeroen Dijsselbloem, head of the Eurogroup for euro zone finance ministers, said the Cyprus bailout represented a new template for resolving regional banking problems and other nations might have to restructure banking sectors to adapt.
His comments caused the euro to reverse initial rallies and suffer heavy losses early in Asia on Tuesday, weakening demand for dollar-denominated commodities from buyers holding the European currency.
"The process itself is a reminder that there is still a lot of risk in Europe," said Ric Spooner, chief market analyst at CMC Markets. This seemed to be a "matter of short-term crisis management by politicians and the conflicting interests of different credit nations were in evidence," he added.
Brent crude futures gained five cents to $108.22 a barrel by 0548 GMT, after slipping to a low of $107.95 earlier. U.S. crude increased by six cents to $94.87.
While the Cyprus bailout removed the immediate risk of a financial meltdown that could have ejected the Mediterranean island from the euro zone, investors remained worried about more potential problems for the country and euro zone.
"That sort of conflict of interest, which could have caused the Cyprus situation to get out of control, and that kind of risk, is still very much with us in Europe," Spooner said.
After reaching an 11th-hour deal with the European Union, the European Central Bank and the International Monetary Fund to shut down the country's second largest bank in return for 10 billion euros in rescue funds, the president of Cyprus assured citizens the deal was in their best interests.
But banks will remain closed until Thursday and even then subject to capital controls to prevent a run on deposits.
NAIMI COMMENTS
Oil prices were also kept in check after Saudi Arabia's oil minister, Ali al-Naimi, said on Monday a price around $100 a barrel was reasonable for consumers and producers, highlighting the top crude exporter's preferred range.
Brent prices in mid-February pushed above $119 a barrel to their highest level this year, before pulling back on economic concerns and improving North Sea supply.
Investors are now watching to see if the strength in the U.S. dollar will be sustained and what happens with U.S. oil inventories later in the day, Spooner said.
Brent's premium to U.S. crude was trading steady at $13.37 a barrel by 0552 GMT on Tuesday, after narrowing to $12.85 in the previous session, the narrowest since early July.
"From a fundamental perspective, a further narrowing will be tricky to achieve in the short term as certain volumes of light-sweet crudes require a (WTI-Brent) spread of around -$15 to be viable for rail transport in the long run," JBC Energy analysts wrote in a note.
"However, as markets tend to overshoot, it is possible that the spread will attempt to test last year's highs, which were around -$11."
U.S. commercial crude oil stockpiles are forecast to have increased by 1.1 million barrels last week on an expected rise in imports, ahead of weekly industry data later in the day, a preliminary Reuters survey of analysts showed on Monday.
Gasoline and distillate inventories are forecast to have slipped by 1.2 million barrels each.
Source: http://news.yahoo.com/brent-steady-near-108-worries-over-cyprus-euro-064130079--finance.html
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Gay Marriage and States' Rights: A Reason.com Debate - Reason.com
MORE ARTICLES BY Jonathan Adler
To help answer these questions, Reason.com invited Ilya Shapiro, a senior fellow in constitutional studies at the Cato Institute, and Jonathan H. Alder, the Johan Verheij Memorial professor of Law at the Case Western Reserve University School of Law, to debate federalism and gay marriage. In the first essay below, Shapiro argues that federalism is beside the point in the Prop. 8 case. In response, Adler argues that while state opposition to same-sex marriage may be unwise, it is not unconstitutional.
Federalism Is Beside the Point in Gay Marriage Lawsuits
Ilya Shapiro
Some libertarians are conflicted over what the U.S. Supreme Court should do when presented with challenges to state laws that don?t allow for same-sex marriage. While consenting adults should be allowed to do whatever they want if it doesn?t harm others, isn?t family law a core function of state sovereignty with which the federal government?including the judiciary?shouldn?t interfere?
That intuition isn?t surprising, because libertarians generally like federalism. Particularly in this age of an overweaning federal government and unaccountable executive branch, we pound our pocket Constitutions and demand respect for the Commerce Clause, the 10th Amendment, and other structural protections for liberty.
Indeed, federalism ?is more than an exercise in setting the boundary between different institutions of government for their own integrity,? wrote Justice Anthony Kennedy for a unanimous Supreme Court in the 2011 case of United States v. Bond (which is returning to the Court this fall). ?By denying any one government complete jurisdiction over all the concerns of public life,? Kennedy continued, ?federalism protects the liberty of the individual from arbitrary power.? If the federal government acts outside the scope of its delegated and carefully enumerated powers, then it?s no better than an armed mob.
I?ve therefore been proud to file federalism-based briefs on the Cato Institute?s behalf on issues ranging from the civil commitment of sex offenders to Obamacare?s individual mandate to the Voting Rights Act. I yield to no one in fighting to keep the federal government within its constitutional bounds.
And yet all that federalism talk is an irrelevant red herring when it comes to gay marriage because there?s no claim here that the federal government is exceeding its lawful authority. Instead, in Hollingsworth v. Perry, the plaintiffs argue that California?s Proposition 8 improperly denies them the fundamental right to marry under the 14th Amendment.
In other words, Perry involves claims that a state government is violating individual constitutional rights, not that the federal government is exercising powers it doesn?t have.?
The lawsuit isn?t some novel invention designed to avoid implicating the Constitution?s structural provisions, but the sort of thing that libertarians get behind without controversy in areas ranging from gun rights to property rights to the right to be free from unreasonable search and seizure. And just as there wasn?t a federalism problem when the Supreme Court struck down Chicago?s gun ban in McDonald v. Chicago, there would be no federalism problem if it now struck down California?s ban on same-sex marriage.
Now, I don?t mean to suggest that Perry is a slam-dunk case that the plaintiffs will easily win. What I?m simply saying is that the case turns on whether treating couples differently on the basis of sexual orientation is constitutionally valid. Perry asks whether the Due Process or Equal Protection Clauses of the Fourteenth Amendment protect the claimed right to marry someone of the same sex. (Full disclosure: Cato filed a brief, which I signed, arguing that the Equal Protection Clause does indeed require states to allow same-sex couples to marry?though in my ideal world the government would get out of the marriage-licensing business altogether.)
Let me state the background principle: If a state law violates a constitutionally protected right, the federal judiciary has the constitutional authority to strike down that law. Indeed, if federal courts decline to do so?if they engage in judicial ?abdication? or ?pacifism??they fail their constitutional duty. Of course, if the state action doesn?t rise to the level of constitutional injury, then courts should rule for the state.
And so if it?s unconstitutional for California to discriminate based on sexual orientation when doling out marriage licenses, then a ruling against Prop 8 would simply vindicate individual constitutional rights. If, however, there?s a compelling reason for making the distinction?because, say, it promotes child-rearing?then California can keep doing what it?s doing. Either way, California?s power to regulate marriage isn?t implicated?just like its power over criminal law wasn?t in doubt in 2011 when the Court found the state?s ban on violent videogames to violate the First Amendment.
In sum, those who argue that federal courts have no business policing state marriage laws are forgetting that the Civil War Amendments, particularly the 14th, fundamentally changed?perfected?our federalism. Since 1868, when states violate individual rights, they have to answer to federal courts.
Source: http://reason.com/archives/2013/03/25/gay-marriage-and-states-rights
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Federal Internet Marketing for Victoria Businesses Offered in 3 Phases
Thunder Bay, Ontario (March 6, 2013) - Federal Internet Marketing is reaching out to businesses in Victoria, BC. The company provides expertise on internet marketing for Victoria businesses to get in the top search engine results using a three-phase method.
The first phase or starting point sees the company identifying and refining ways that affect businesses? appeal to their customers. It provides tools in terms of copywriting, website creation or redesign, and reputation marketing and review systems that can develop and feature clients? images and branding on the Internet. Should clients be happy, they can proceed to the next phase.
The second phase involves putting client businesses? branding and information everywhere possible on the Web where an online user is likely to be when searching. Federal Internet Marketing makes use of search engine optimization, local SEO, online advertising, and referral incentives to get more people to find out about their clients. A third phase awaits those ready to go to the next level.
The final phase has the company developing and maintaining the relationships formed with clients? end consumers through various forms of media. Aside from reputation and review systems as mentioned earlier, Federal can also utilize email and text campaigns, social engagement in industry appropriate sites, and even mobile web presence to reach the incredible growing amount of people who go online using smart phones and tablets.
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Tuesday, March 26, 2013
Leaked Windows Blue build 9364 reveals multiple Live Tile sizes, same-width side-by-side apps
Want to get a first-hand look at Microsoft's updated OS? You might be able to download the unreleased Windows Blue operating system on your own machine. Leaked build 9364 hit file sharing sites earlier today -- according to Neowin, the 32-bit edition is available for download as a 2.63GB ISO, and likely hit the web from a Microsoft partner in France. Notable adjustments include larger and smaller Live Tiles, enabling a bit more Start screen customization, along with an updated side-by-side app view, which boosts multitasking efficiency by displaying two applications with matching width. Other additions include a Play option under the Devices panel, a screenshot button on the Share sidebar, and Internet Explorer 11, which comes packaged with the new OS. Windows Blue build 9364 appears to be an unauthorized leak, but even if you have any reservations about installing it on your own machine, you'll surely be able to check out plenty of eye candy from other users over the hours and days to come. In the meantime, hit up the source links for a few more screenshots.
[Thanks, Jim]
Filed under: Software, Microsoft
Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/Y3gil7kCzqU/
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Jacked Up Baking: Part II | Food+Drink
Last week I brought you a mouth watering pie recipe and today is part two of my boozed up baking experience! I present to you our Maple Bourbon Hot Chocolate.?
Unlike the pie recipe that was passed on to me from a friends mother, this hot chocolate recipe was found?online. At first, we were courageously going to attempt to make a bacon whipped cream, but decided against it because it sounded too?riskay?and somewhat disgusting. We instead settled for a simple whipped cream with a splash of Jack for some extra pizazz! I then topped it off with a few extra pieces of leftover maple bacon we had used for the pie? probably not the best idea because they then sunk to the bottom of my glass and proceeded to get soggy. So, ensure you do?not?add bacon. Whipped cream will do just fine. Besides, the drink itself is quite boozey and delicious as it is!
Keep in mind we made the pie and hot chocolate on the same day, so it was an overload of Jack Daniels. I?d highly suggest not to pair these two things together or you might be drunk by the end of it. (But maybe that?s not such a bad thing?)
- 2 ? cup whole milk
- ? cup dark chocolate
- 1 tbl spoon dark brown sugar
- 2 tbl spoons maple syrup
- Pinch of salt
- ? cup of bourbon
Step 1?
Finely chop the chocolate into small pieces. Be careful not to chop your fingers off, you need them. The pieces should be able to dissolve easily in the liquid.
Step 2
Pour milk into a small pot on low heat and bring to a simmer.?Whisk once in a while to ensure that the milk doesn?t stick to the bottom of the pan.
Step 3
Add the chocolate, brown sugar (we had no brown sugar so we used regular sugar. Sugar is sugar in my mind!), maple syrup and salt.
Step 4
Whisk vigorously until chocolate has melted. ?Heat for another 4 minutes, constantly stirring. Make sure no chocolate sticks to the bottom of the pot. Trust me, that shit is a bitch to clean off.
Step 5
Now for the best part! Add the bourbon (we used Jack Daniels) at the last minute.
Step 6
Take some whipping cream and whisk until fluffy. Add a teaspoon/splash,/whole bottle if you like, into the mixture. If you want your whipped cream a little sweeter just add some sugar.
?Step 7
Pour into a mug?and add some whipped?cream. Sip on that! Pure bliss!
Amanda Gabrielli is a foodie and freelance photographer, always aiming to make people laugh along at her crude humour. You can find her on Twitter @amandarachel?and Instagram @mandzzzzz. All photos credited to Amanda Gabrielli.
Amanda
This Florida born, Montreal raised, eccentric lady is Amanda; but most people call her Mandz. She's outspoken, swears like a sailor and complains about everything. Her literary and photography background combined with her extreme love for food make for entertaining reads and tantalizing photographs.
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Source: http://www.themainmtl.com/2013/03/25/jacked-up-baking-part-ii/
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